Dosing Calculator

COSENTYX (for IV use) must be diluted prior to infusion. Using aseptic technique, prepare COSENTYX (for IV use) as follows:

Step 1:

Volume calculation

Calculate the total volume of COSENTYX for IV use solution required based on the patient’s actual body weight as follows:
- Loading dose is 0.24 mL/kg or 6 mg/kg
- Maintenance dose is 0.07 mL/kg or 1.75 mg/kg
Use the number of vials based on total volume needed (1 vial contains 5 mL or 125 mg of COSENTYX solution)

Step 2:

Dilution

Before dilution, allow the COSENTYX solution in vial(s) to sit for approximately 20 minutes at room temperature 20-25 °C (68-77 °F)
Parenteral drug product should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if particulates or discolorations are noted
Follow the table below for recommended infusion-bag size based on patient’s body weight

Recommended infusion bags for dilution and preparation of COSENTYX for IV use based on body weight and dose

Dosing Table
Body weight at time of dosing	For loading dose (6 mg/kg) recommended infusion bag	For maintenance dose (1.75 mg/kg) recommended infusion bag
>52 kg	100 mL	100 mL
≤52 kg	100 mL	50 mL*

^*If a 50-mL infusion bag is unavailable, then use a 100-mL infusion bag and withdraw and discard 50 mL of saline using aseptic technique and continue to follow the preparation and administration steps.

From the infusion bag, withdraw and discard a volume of 0.9% Sodium Chloride Injection, USP equal to the calculated volume of the COSENTYX concentrate solution required for the patient’s dose
From the vial(s), withdraw the calculated volume (mL) of COSENTYX solution and add slowly into the 0.9% Sodium Chloride Injection, USP infusion bag. To mix the solution, gently invert the bag to avoid foaming. Do not shake

Discard unused COSENTYX product in vials because it does not contain preservatives
Administer the diluted COSENTYX solution for infusion as soon as possible. If not administered immediately, store the diluted solution either:
- At room temperature 20-25 °C (68-77 °F) for no more than 4.5 hours from the start of the preparation (piercing the first vial) to the completion of infusion
- Under refrigeration at 2-8 °C (36-46 °F) for no more than 24 hours from the start of the time of the preparation (piercing the first vial) to the completion of infusion. This time includes the refrigeration of the diluted solution and the time to allow the diluted solution to warm to room temperature. Protect the diluted solution from light during storage under refrigeration

Step 3:

Administration

Use only an infusion set with an in-line, sterile, nonpyrogenic, low-protein-binding filter (pore size 0.2 micrometer)
Administer the infusion at a flow rate of about 3.3 mL/min for a 100-mL bag or 1.7 mL/min for a 50-mL bag (total administration time: 30 minutes)
When administration is complete, flush the line with at least 50 mL of 0.9% Sodium Chloride Solution, USP to guarantee that all the diluted COSENTYX solution for infusion in the line has been administered
Do not infuse COSENTYX concomitantly in the same IV line with other drugs. No physical or biochemical compatibility studies have been conducted to evaluate the IV coadministration of COSENTYX with other drugs